Improved the appearance of slider controls on macOS and fixed an issue that prevented vertically scaling peaks for traces aligned to a reference sequence.Improved the appearance of tab controls on macOS.Fixed an issue where quality of sequences aligned to a reference was sometimes not shown when requested.Zoom to fit by default when viewing RNA secondary structures.Show complementary bases of neighboring overhangs in Golden Gate cloning mini-overviews.Added links to NEBuilder® HiFi DNA Assembly and TOPO® Cloning tutorial videos.Modernized application, file, and various other icons.Improved the default sequence name when pasting FASTA encoded sequences into the New File dialog.Updated the Golden Gate Assembly dialog to include easy access to recommended enzymes.Improved the error message shown when attempting to ligate linear fragments that lack 5' terminal phosphates.Display the selected MW in the selection bar for protein alignments. Improved the appearance of many icons on low DPI displays.Check for and prevent simulating Golden Gate assembly if two adjacent fragments are set to be used directly and abutting ends both lack 5' terminal phosphates.Copy or export the properties and amino acid data for full protein sequences or selected regions.When using automatic primer design, the hybridized region will be configured automatically, ensuring miscellaneous features are not transferred to the product when a 5’ primer extension by chance partially hybridizes to the template. Adjust the hybridization region for all PCR cloning simulations.Adjust overhangs for manually designed primers while simulating Golden Gate Assembly.Cut a Golden Gate Assembly vector with any enzyme (not just Type IIS enzymes).Added a ligation fidelity matrix to the Golden Gate Assembly tool for assessing overall reaction fidelity.Added menu actions at the top right of Structure view to reset pane, rotation and scale.Coordinates and 5' / 3' end labels can optionally be displayed in Structure view.Display and make sequence selections in Structure view.RNA structures can be recalculated using adjusted Tm and other settings.
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